Diabetic neuropathic pain (DNP), one of the early symptoms of diabetic neuropathy, relates to metabolic disorders induced by high\nblood glucose, neurotrophic vascular ischemia and hypoxia, and autoimmune factors. This study was aimed at exploring the effects\nof long noncoding RNA (lncRNA) BC168687 siRNA on DNP mediated by P2X7 receptor on SGCs inDRGof rats.The mechanical\nwithdrawal threshold (MWT) and thermal withdrawal latency (TWL) of rats, the expression levels of P2X7 mRNA and protein in\nthe DRG, and nitric oxide (NO) in the serum were, respectively, detected in our study. Our experimental results showed that the\nlevel of BC168687mRNA inDNP group wasmarkedly higher than that of control group; theMWTand TWL ofDNP + BC168687\nsi group were significantly increased, and the expression levels of P2X7 in DRG and the concentrations of NO in serum of DNP\n+ BC168687 si group were decreased compared to those of the DNP group. In conclusion, lncRNA BC168687 may participate in\nthe pathogenesis of DNP mediated by P2X7 receptor, which will provide a novel way for the study of the pathogenesis of diabetes\nmellitus complicated with neuropathic pain and its prevention and treatment.
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